Keshav and Anjali Kumar, two young siblings from Jharkhand, India suffer from two rare conditions known as Cutis Laxa and Progeria, which make them look incredibly old for their age.

The Indian brother and sister originally made news headlines as the “Benjamin Button siblings” in 2016. Anjali was 7 at the time, and her younger brother was only 18-months-old, but they both already looked like octogenarians. And not only was their skin unusually wrinkly and saggy, but they both suffered from joint pain associated with old age. This paradoxical situation earned them the nickname ‘Benjamin Button siblings,’ after the fictional character in F. Scott Fitzgerald’s short story. Keshav and Anjali Kumar were diagnosed with progeria and cutis laxa, two exceptionally rare conditions that are, unfortunately, incurable.

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Raizel Calago is only 16-years-old, but you would never guess just by looking at her. She suffers from a rare condition called progeria which makes her look four times her age.

In only two years, Raizel Calago went from a beautiful young girl who attended beauty pageants, to an old-looking woman that many people mistake for a grandmother. The young Filipina says that she started noticing wrinkles in her skin just days after rashes erupted all over her body. Red, itchy patches that were painful to the touch appeared on her body, and when she went for a checkup, she was told that they had been caused by an insect. She was given medication, but that didn’t help, and soon she started noticing physical changes to her appearance. Now, it’s hard to believe she is just 16-years-old…

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It’s not every day that you hear about teenage girls turning to plastic surgery to make themselves look more youthful, but then again, not many 15-year-olds look like their grandmothers.

The story of Xiaofeng, a young girl from Liaoning, China, who suffered from a rare medical condition that left her looking like a woman in her 60’s, first made news headlines in December of last year. Media outlets throughout Asia wrote about how the first symptoms of the incurable condition known as progeria appeared when Xiaofeng was just one-year-old, and how by the time her teenage years rolled up, she looked like an old woman. Her saggy skin made her the target of cruel kids at school, and the constant abuse made her decide to quit her studies. The sad story melted the hearts of millions, many of which donated money for a surgery that could help the poor girl look her age.

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